BEND3 is involved in the human-specific repression of calreticulin: Implication for the evolution of higher brain functions in human
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- 作者：A. Aghajanirefaha ; L.N. Nguyena ; M. Ohadib ; ohadi.mina@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：BEND3 ; BEN domain containing 3 ; CALR ; Calreticulin ; NFI ; Nuclear factor I ; VPA ; Valproic acid
- 刊名：Gene
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：576
- 期：1
- 页码：577-580
- 全文大小：709 K
文摘
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Enormous nucleotide conservation at CALR promoter rs138452745 across evolution, except in the human species.
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BEND3 binds to the rs138452745 human-specific C-allele.
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NF1A, B, C, and X bind to the rs138452745 ancestral A-allele.
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Binding of BEND3 and removal of NFI binding to the rs138452745 C-allele may be linked with human-specific brain functions.