ErbB signaling in cardiac development and disease
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- 作者：Pablo Sanchez-Soria ; Todd D. Camenisch
- 关键词：ErbB ; Heart development ; Heart disease ; Mouse models ; Cardiotoxicity ; Therapeutics
- 刊名：Seminars in Cell and Developmental Biology
- 出版年：2010
- 出版时间：December 2010
- 年：2010
- 卷：21
- 期：9
- 页码：929-935
- 全文大小：392 K
文摘
The ErbB family of receptor tyrosine kinases (RTKs) is a family of receptors that allow cells to interact with the extracellular environment and transduce signals to the nucleus that promote differentiation, migration and proliferation necessary for proper heart morphogenesis and function. This review focuses on the role of the ErbB family of receptor tyrosine kinases, and their importance in proper heart morphogenesis, as well as their role in maintenance and function of the adult heart. Studies from transgenic mouse models have shown the importance of ErbB receptors in heart development, and provide insight into potential future therapeutic targets to help reduce congenital heart defect (CHD) mortality rates and prevent disease in adults. Cancer therapeutics have also shed light to the ErbB receptors and signaling network, as undesired side effects have demonstrated their importance in adult cardiomyocytes and prevention of cardiomyopathies. This review will discuss ErbB receptor tyrosine kinases (RTK) in heart development and disease including valve formation and partitioning of a four-chambered heart as well as cardiotoxicity when ErbB signaling is attenuated in adults.