Catalysis of fluorine addition to double bond: An improvement of method for synthesis of ¹⁸F PET agents

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• 作者：Alex ; er V. Kachur ; William R. Dolbier Jr. ; Wei Xu ; Cameron J. Koch
• 关键词：Electrophylic fluorination ; ¹⁸F-labeling ; Catalysis ; EF5
• 刊名：Applied Radiation and Isotopes
• 出版年：2010
• 出版时间：February 2010
• 年：2010
• 卷：68
• 期：2
• 页码：293-296
• 全文大小：314 K

文摘

Catalysis for reaction of electrophilic fluorine addition to a fluorinated double bond is described. The presence of small amounts of iodine, bromine, or boron trifluoride increases an overall product yield and degree of fluorine incorporation, making the reaction a more efficient method for preparation of ¹⁸F positron emission tomography agents. A possible mechanism of catalytic action of iodine is discussed.