Left Ventricular Myocardial and Hemodynamic Response to Exercise in Young Patients after Endovascular Stenting for Aortic Coarctation

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• 作者：Ching Kit Chen ; MD ; Barbara Cifra ; MD ; Gareth J. Morgan ; MD ; Taisto Sarkola ; MD ; Cameron Slorach ; RDCS ; Hui Wei ; MD ; Timothy J. Bradley ; MBChB ; Cedric Manlhiot ; BSc ; Brian W. McCrindle ; MD ; Andrew N. Redington ; MD ; Lee N. Benson ; MD ; Luc Mertens ; MD ; PhD ; ^{luc.mertens@sickkids.ca" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Coarctation of the aorta ; Endovascular stent ; Echocardiography ; Isovolumic acceleration ; Exercise ; Force-frequency relationship
• 刊名：Journal of the American Society of Echocardiography
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：29
• 期：3
• 页码：237-246
• 全文大小：1090 K

文摘

Endovascular stenting has emerged as a treatment option for children with coarctation of the aortic (CoA), but the impact on left ventricular (LV) function has been poorly documented. The aim of this study was to characterize the LV myocardial and hemodynamic response to exercise in young patients who underwent endovascular stenting for CoA during childhood using semisupine bicycle exercise stress echocardiography.

Methods

This was a single-center prospective cross-sectional study including 30 patients with CoA and 30 age- and gender-matched control subjects who underwent semisupine bicycle exercise stress echocardiography. Color Doppler tissue imaging peak systolic (s′) and early diastolic (e′) velocities in the LV lateral wall and basal septum, LV myocardial acceleration during isovolumic acceleration were measured at rest and with incremental heart rate (HR). The relationship with increasing HR was evaluated for each parameter by plotting the values at each stage of exercise versus HR.

Results

At rest, HR was similar between the two groups. LV ejection fraction and fractional shortening were within the normal range in the CoA group. LV lateral wall and basal septal s′ and e′ velocities did not differ between the two groups, but isovolumic acceleration values were significantly lower in the CoA group. At peak exercise, HR was similar between the groups, but all Doppler tissue imaging parameters were lower in patients than in control subjects. When assessing the increase of each parameter versus HR, the increase in slope was significantly lower in patients than in control subjects for LV lateral wall Doppler tissue imaging s′ and e′ velocities, and septal e′ velocity, but not for septal s′. The relationship of isovolumic acceleration with HR was significantly reduced in the CoA group.

Conclusion

The results of this study demonstrate reduced systolic and diastolic myocardial reserve in patients with CoA compared with control subjects. An abnormal myocardial contractile response to exercise was also found, as shown by an abnormal LV force-frequency relationship in patients with stented CoA. The prognostic clinical implications require further study.