Comparison of ω-3 fatty acids and sulfasalazine in ulcerative colitis

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• 作者：Dichi ; Isaias ; Frenhane ; Patrí ; cia ; Dichi ; Jane B. ; Correa ; Camila R. ; Angeleli ; Aparecida Y.O. ; et. al.
• 关键词：ulcerative colitis ; sulfasalazine ; ω ; -3 fatty acids ; disease activity indicators ; protein metabolism ; ¹⁵N-glycine
• 刊名：Nutrition
• 出版年：2000
• 出版时间：February, 2000
• 年：2000
• 卷：16
• 期：2
• 页码：87-90
• 全文大小：47.7 K

文摘

Fish oil ω-3 fatty acids exert antiinflammatory effects on patients with ulcerative colitis. However, a comparative study in patients with mild to moderate ulcerative colitis receiving only sulfasalazine or ω-3 fatty acids has not been performed. We sought to detect changes in the inflammatory disease activity with the use of either fish oil ω-3 fatty acids or sulfasalazine in patients with ulcerative colitis. Ten patients (five male, five female; mean age = 48 ± 12 y) with mild to moderate active ulcerative colitis were investigated in a randomized cross-over design. They received either sulfasalazine (2 g/d) or ω-3 fatty acids (5.4 g/d) for 2 mo. Disease activity was assessed by clinical and laboratory indicators, sigmoidoscopy, histology, and whole-body protein turnover (with ¹⁵N-glycine). Treatment with ω-3 fatty acids resulted in greater disease activity as detected by a significant increase in platelet count, erythrocyte sedimentation rate, C-reactive protein, and total fecal nitrogen excretion. No major changes in protein synthesis and breakdown were observed during either treatment. In conclusion, treatment with sulfasalazine is superior to treatment with ω-3 fatty acids in patients with mild to moderate active ulcerative colitis.