Protein sorting into multivesicular endosomes
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- 作者：Raiborg ; Camilla ; Rusten ; Tor Erik ; Stenmark ; Harald
- 关键词：EGF ; epidermal growth factor ; ESCRT ; endosomal sorting complex required for transport ; FYVE ; conserved in Fab1p/YOTB/Vac1p/EEA1 ; LBPA ; lyso-bisphosphatidic acid ; MVE ; multivesicular endosome ; LRP ; low-density lipoprotein receptor related protein ; PI3P ; Pt
- 刊名：Current Opinion in Cell Biology
- 出版年：2003
- 出版时间：August, 2003
- 年：2003
- 卷：15
- 期：4
- 页码：446-455
- 全文大小：1.09 M
文摘
Multivesicular endosomes are important as compartments for receptor downregulation and as intermediates in the formation of secretory lysosomes. Work during the past year has shed light on the molecular mechanisms of protein sorting into multivesicular endosomes and yielded information about the machinery involved in multivesicular endosome formation. Monoubiquitination functions as a signal for sorting transmembrane proteins into intraluminal vesicles of multivesicular endosomes and subsequent delivery to lysosomes. A molecular machinery that contains the ubiquitin-binding protein Hrs/Vps27 appears to be central in this sorting process. Three conserved multisubunit complexes, ESCRT-I, -II and -III, are essential for both sorting and multivesicular endosomes formation. Enveloped RNA viruses such as HIV can redirect these complexes from multivesicular endosomes to the plasma membrane to facilitate viral budding.