Blood manganese levels in patients with hepatic encephalopathy

详细信息    查看全文

• 作者：Hugo Mendieta Zeró ; n^a ; ^{mezh_74@yahoo.com} ; Mó ; nica Rodrí ; guez Rodrí ; guez^b ; Sergio Montes^c ; Camilo Rí ; os Casta&ntilde ; eda^c
• 关键词：Child-Pugh ; Hepatic encephalopathy ; Prognosis ; Women
• 刊名：Journal of Trace Elements in Medicine and Biology
• 出版年：2011
• 出版时间：December, 2011
• 年：2011
• 卷：25
• 期：4
• 页码：225-229
• 全文大小：1K

文摘

Project

Hepatic encephalopathy is an increasingly common disease. Identification of prognosis risk factors in patients with liver damage may lead to preventive actions, towards decreasing its mortality. Manganese (Mn) levels are increased in basal ganglia of patients with hepatic encephalopathy as well as in cases of cirrhotic and liver failure patients. The present is a clinical, prospective, prolective and observational study developed at the Internal Medicine Service from ¡°Dr. Dar¨ªo Fern¨¢ndez Fierro?General Hospital, ISSSTE, Mexico City. The objective of this work was to report whole blood Mn levels and mortality in encephalopathic patients.

Procedure

Consecutive patients over 18 years of age, diagnosed with hepatic encephalopathy were recruited at the emergency room service. An informed consent, signed by their families was collected. Patients?clinical characteristics, biochemical tests of renal function, hemoglobin, glucose, bilirubins and albumin levels were obtained along with a blood sample to analyze Mn. Patients evolution was followed up for 6 months.

Results

Blood Mn in patients [median, (range)] [20.5, (10.5-39.5) ¦Ìg/L] were higher than blood levels from a group of healthy volunteers [7.5, (6.1-12.8) ¦Ìg/L] (P < 0.001). Among 9 patients studied four died, 2 women and 2 men, those patients showed higher (P = 0.032) Mn levels [28, (17-39.5) ¦Ìg/L] than those alive [13.5, (10.5-32) ¦Ìg/L] after the follow up period.

Conclusions

In this pilot study, Mn blood levels were higher in hepatic encephalopathy that died as consequence of the disease that those that survived in a 6 month follow up period. Blood Mn could be a potential prognosis factor for death in patients with hepatic encephalopathy.