Mapping the response of human fibroblast growth factor 21 (FGF21) promoter to serum availability and lipoic acid in HepG2 hepatoma cells
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- 作者：Mengna Xia1 ; Anjeza Erickson1 ; Xiaohua Yi1 ; Ré ; gis Moreau ; rmoreau2@unl.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACTB ; β-actin ; CPT1A ; carnitine palmitoyltransferase 1α ; CBP ; CREB binding factor ; CREB ; cAMP response element-binding protein ; DHLA ; DL-α-dihydrolipoic acid ; Elk-1 ; ETS domain-containing Elk-1 ; Elk-4 ; ETS domain-containing Elk-4 (aka SAP-1) ; ENCODE ; encyclopedia of DNA elements ; ERK1/2 ; extracellular signal-regulated protein kinases 1 and 2 ; ERK5 ; extracellular signal-regulated kinase 5 ; ETS ; E26 transformation specific sequence ; FAIRE ; formaldehyde-assisted isolation of regulatory elements ; FG
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：1860
- 期：3
- 页码：498-507
- 全文大小：1242 K
文摘
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mRNA de novo synthesis drives FGF21 production in response to serum starvation.
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Lipoic acid potentiates serum withdrawal-dependent increase in FGF21 secretion.
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Lipoic acid cell signaling connects with FGF21 transcriptional pathway.
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Serum withdrawal and lipoic acid treatment alter the structure of FGF21 promoter.
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FGF21 may mediate the metabolic properties of lipoic acid.