| Fi
gures/TablesFi
gures/Tables | ReferencesReferencesg=""UTF-8""?>
Summary
The Tasmanian devil (
Sarcophilus harrisii), the lar
gest marsupial carnivore, is endan
gered due to a transmissible facial cancer spread by direct transfer of livin
g cancer cells throu
gh bitin
g. Here we describe the sequencin
g, assembly, and annotation of the Tasmanian devil
genome and whole-
genome sequences for two
geo
graphically distant subclones of the cancer. Genomic analysis su
ggests that the cancer first arose from a female Tasmanian devil and that the clone has subsequently
genetically diver
ged durin
g its spread across Tasmania. The devil cancer
genome contains more than 17,000 somatic base substitution mutations and bears the imprint of a distinct mutational process. Genotypin
g of somatic mutations in 104
geo
graphically and temporally distributed Tasmanian devil tumors reveals the pattern of evolution and spread of this parasitic clonal linea
ge, with evidence of a selective sweep in one
geo
graphical area and persistence of parallel linea
ges in other populations.
PaperClip