Effect of [Cu(4,7-dimethyl-1,10-phenanthroline)(acetylacetonato)]NO3, Casiopeína III-Ea, on the activity of cytochrome P450
详细信息 查看全文
- 作者：Cristina Campero-Peredoa ; Marí ; a Elena Bravo-Gó ; mezb ; mebravo@unam.mx" class="auth_mail" title="E-mail the corresponding author ; ma_elenab@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Sandra Luz Herná ; ndez-Ojedac ; Sitlali del Rosario Olguin-Reyesc ; Javier J. Espinosa-Aguirrec ; Lena Ruiz-Azuaraa
- 关键词：Casiopeí ; na III-Ea ; CYP1A1 ; Competitive inhibitors of cytochromes ; Copper complexes ; Antitumor compounds ; Metal-based drugs
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：33
- 期：Complete
- 页码：16-22
- 全文大小：712 K
文摘
- •
CasIII-Ea is not biotransformed by CYP1A1.
- •
Cas III-Ea is a strong competitive and irreversible inhibitor of CYP1A1.
- •
Copper (II) and 4,7-dimethyl-1,10-phenanthroline are the structural determinants required for inhibition.