A seventeen-year observation of the antimicrobial susceptibility of clinical Campylobacter jejuni and the molecular mechanisms of erythromycin-resistant isolates in Beijing, China
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- 作者：Jiyuan Zhoua ; 1 ; Maojun Zhangb ; c ; 1 ; Wanna Yanga ; Yuqing Fanga ; Guiqiang Wanga ; john131212@sina.com" class="auth_mail" title="E-mail the corresponding author ; Fengqin Houa ; houfqys@139.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Campylobacter jejuni ; Resistance ; Erythromycin ; Molecular mechanism
- 刊名：International Journal of Infectious Diseases
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：42
- 期：Complete
- 页码：28-33
- 全文大小：365 K
文摘
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Significantly increasing rates of antimicrobial resistance were found in clinical Campylobacter jejuni isolated in China between 1994 and 2010.
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Macrolides are still the most effective antibiotics for human campylobacteriosis in this region.
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The molecular mechanisms including 23S rRNA, ermB, and the regulatory region of the CmeABC operon might be involved in erythromycin resistance.
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This study revealed that more stringent monitoring and regulation of human and animal antimicrobial use is warranted in this region.