Tumorigenesis of smoking carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is related to its ability to stimulate thromboxane synthase and enhance stemness of non-small cell lung cancer stem cells
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- 作者：Yi Liua ; b ; 1 ; Shucai Yanga ; 1 ; Ming-Yue Lia ; Runyue Huangc ; Calvin S.H. Nga ; Innes Y.P. Wana ; Xiang Longd ; Jun Wue ; Bin Wue ; Jing Dud ; Tony S.K. Mokf ; Malcolm J. Underwooda ; ; George G. Chena ; gchen@cuhk.edu.hk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lung cancer ; Stem cells ; Smoking ; NNK ; Thromboxane
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 January 2016
- 年：2016
- 卷：370
- 期：2
- 页码：198-206
- 全文大小：2835 K
文摘
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Blocking of thromboxane synthase suppresses NNK-induced lung tumorigenesis.
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NNK enhances lung cancer stem cells via stimulating thromboxane synthase to activate Akt/GSK3β/β-catenin/Nanog pathway.
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Targeting thromboxane synthase appears to be a promising therapeutic option for smoking-related lung cancer.