In vivo relevant mixed urolithins and ellagic acid inhibit phenotypic and molecular colon cancer stem cell features: A new potentiality for ellagitannin metabolites against cancer
详细信息 查看全文
- 作者：Marí ; a Á ; ngeles Nú ; ñ ; ez-Sá ; ncheza ; Ankur Karmokarb ; Antonio Gonzá ; lez-Sarrí ; asa ; Rocí ; o Garcí ; a-Villalbaa ; Francisco A. Tomá ; s-Barberá ; na ; Marí ; a Teresa Garcí ; a-Conesaa ; mtconesa@cebas.csic.es" class="auth_mail" title="E-mail the corresponding author ; Karen Brownb ; Juan Carlos Espí ; na ; jcespin@cebas.csic.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Colon cancer ; Ellagic acid ; Urolithins ; Stem cells ; Metabotype ; Chemoprevention
- 刊名：Food and Chemical Toxicology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：92
- 期：Complete
- 页码：8-16
- 全文大小：817 K
文摘
- •
Microbiota phenolic-derived metabolites can battle colon cancer stem cells (CSCs).
- •
Urolithins (Uros) and ellagic acid (EA) inhibit CSC features in vitro and ex vivo.
- •
Mixed Uros and EA inhibit the formation and growth of colonospheres.
- •
Mixed Uros and EA reduce ALDH-expressing cell population of CSCs.
- •
Potential effect of Uros on the recurrence and chemoresistance of colon cancer.