APBB1 reinforces cancer stem cell and epithelial-to-mesenchymal transition by regulating the IGF1R signaling pathway in non-small-cell lung cancer cells
刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:1 January 2017
年:2017
卷:482
期:1
页码:35-42
全文大小:1968 K
卷排序:482
文摘
APBB1 was highly expressed in ALDH1high cells sorted from A549 cells. APBB1 is associated with intensifying CSC and EMT and enhancing radiation-resistant properties of lung cancer cells. APBB1 regulates EMT-associated CSC-like properties and γ-radiation resistance via activation of IGF1Rβ/AKT/GSK3β pathway. APBB1 partly regulates the expression of ALDH1 via AKT/GSK3β-associated β-catenin pathway.