Improving enantioselectivity of lipase from Candida rugosa by carrier-bound and carrier-free immobilization
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- 作者：Susana Velasco-Lozanoa ; b ; Fernando Ló ; pez-Gallegob ; Javier Rocha-Martinc ; José ; Manuel Guisá ; nd ; jmguisan@icp.csic.es" class="auth_mail" title="E-mail the corresponding author ; Ernesto Favela-Torresa ; favela@xanum.uam.mx" class="auth_mail" title="E-mail the corresponding author
- 关键词：Immobilization ; Enantioselectivity ; CLEA ; Lipase
- 刊名：Journal of Molecular Catalysis B: Enzymatic
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：130
- 期：Complete
- 页码：32-39
- 全文大小：1437 K
文摘
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Enantioselective reactions were carried out with carrier-bound and carrier-free biocatalysts of lipase from Candida rugosa.
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Lipases-catalyzed enantioselective reactions were significantly enhanced by coupling immobilization techniques and reaction medium conditions.
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The strategies employed herein allowed high enantioselective resolutions of (S)-1-phenylethanol (E > 200) and the ethyl (R)-2-hydroxy-4-phenylbutyrate (E = 39).