Pervanadate induces Mammalian Ste20 Kinase 3 (MST3) tyrosine phosphorylation but not activation
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- 作者：Wei-Chih Kana ; b ; 1 ; Te-Ling Luc ; 1 ; Pin Lingd ; Te-Hsiu Leeb ; Chien-Yu Choe ; Chi-Ying F. Huangf ; Wen-Yih Jenge ; Yui-Ping Wengg ; Chun-Yen Chiangh ; i ; Jin Bin Wuc ; Te-Jung Lub ; lutejung@yahoo.com.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cys ; cysteine ; DMEM ; Dulbecco's modified Eagle's medium ; EGFR ; epidermal growth factor receptor ; GPCR ; G protein-coupled receptor ; HEK 293 ; human embryonic kidney 293 ; HPK1 ; hematopoietic progenitor kinase 1 ; MST ; mammalian Ste20 kinase ; MAP4K ; MAP kinase kinase kinase kinase ; MAP3K ; MAP kinase kinase kinase ; MAP2K ; MAP kinase kinase ; MAPK ; MAP kinase ; MDCK ; Madin-Darby canine kidney ; NMR ; nuclear magnetic resonance ; OA ; okadaic acid ; PAK ; p21-activated kinase ; PLD1 ; phospholipase D1 ; PSP ; prote
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：160
- 期：Complete
- 页码：33-39
- 全文大小：554 K
文摘
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Pervanadate induces Mammalian Ste20 Kinase 3 (MST3) tyrosine phosphorylation.
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MST3 activity is independent of tyrosine phosphorylation in intact cells.
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The Triton concentration and ionic strength of the buffer influence the sensitivity of MST3 activity.
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Tyrosine-phosphorylated MST3 may facilitate adaptor recruitment for subsequent signaling.