New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking

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• 作者：Giulio Ragusa^a ; Marí ; a Gó ; mez-Cañ ; as^b ; ^c ; ^d ; Paula Morales^e ; Carmen Rodrí ; guez-Cueto^b ; ^c ; ^d ; Marí ; a R. Pazos^b ; ^c ; ^d ; Battistina Asproni^a ; Elena Cichero^f ; Paola Fossa^f ; Gerard A. Pinna^a ; Nadine Jagerovic^e ; Javier Ferná ; ndez-Ruiz^b ; ^c ; ^d ; Gabriele Murineddu^a ; ^{muri@uniss.it}
• 关键词：Scaffold hopping ; Synthesis ; Cannabinoid receptors ; CB2 antagonism ; ADME model ; Docking studies
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：398-412
• 全文大小：1393 K
• 卷排序：127

文摘

Synthesis of novel pyridazinone-4-carboxamide derivatives. Pharmacological evaluation: cannabinoid receptors binding and CB2 functionality assays. Molecular modelling studies.