Carbohydrate and the cytokine response to 2.5 h of running

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• 作者：Nehlsen-Cannarella ; S.L. ; Fagoaga ; O.R. ; Nieman ; D.C.
• 刊名：Occupational Health and Industrial Medicine
• 出版年：1997
• 出版时间：1997
• 年：1997
• 卷：37
• 期：2
• 页码：91
• 全文大小：149 K

文摘

This randomized, double-blind, placebo-controlled study was designed to determine the influence of 6 % carbohydrate (C) vs. placebo (P) beverage ingestion on cytokine responses (5 total samples over 9 h) to 2.5 h of high-intensity running (76.7 ± 0.4 % maxima) O₂ uptake) by 30 experienced marathon runners. For interleukin-6 (IL-6), a difference in the pattern of change between groups was found, highlighted by a greater increase in P vs. C immediately postrun (753 vs. 421 % ) and 1.5 h postrun (193 vs. 86 % ) [F(4,112) = 3.77, P = 0.006]. For interleukin-1-receptor antagonist (IL-1ra), a difference in the pattern of change between groups was found, highlighted by a greater increase in P vs. C 1.5 h postrun (231 vs. 72 % ) [F(2,50) = 6.38, P = 0.003]. No significant interaction effects were seen for bioactive IL-6 or IL-1β. The immediate postrun plasma glucose concentrations correlated negatively with those of plasma cortisol (r = 0.67, P < 0.001); postrun plasma cortisol(r = 0.70, P < 0.001) and IL-6 levels (r = 0.54, P = 0.003) correlated positively with levels of IL-1ra. Taken together, the data indicate that carbohydrate ingestion attenuates cytokine levels in the inflammatory cascade in response to heavy exertion.