TGF-β-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination
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- 作者：Gaia Cantelli1 ; Jose L. Orgaz1 ; Irene Rodriguez-Hernandez1 ; Panagiotis Karagiannis2 ; 3 ; Oscar Maiques4 ; Xavier Matias-Guiu4 ; Frank O. Nestle2 ; Rosa M. Marti5 ; Sophia N. Karagiannis2 ; Victoria Sanz-Moreno1 ; victoria.sanz_moreno@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Current Biology
- 出版年：2015
- 出版时间：16 November 2015
- 年：2015
- 卷：25
- 期：22
- 页码：2899-2914
- 全文大小：3865 K
文摘
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TGF-β-SMAD promotes amoeboid migration in melanoma
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Downstream of TGF-β, the adaptor CITED1 controls actomyosin contractility
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Amoeboid features correlate with CITED1 levels in cell lines, xenografts, and patients
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TGF-β-SMAD-CITED1 transcriptional network controls melanoma metastatic ability