Single-dose tenofovir and emtricitabine for reduction of viral resistance to non-nucleoside reverse transcriptase inhibitor drugs in women given intrapartum nevirapine for perinatal HIV prevention: an

详细信息    查看全文

• 作者：Benjamin H Chi ; Moses Sinkala ; Felistas Mbewe ; Ronald A Cantrell ; Gina Kruse ; Namwinga Chintu ; Grace M Aldrov ; i ; Elizabeth M Stringer ; Chipepo Kankasa ; Jeffrey T Safrit ; Jeffrey SA Stringer
• 关键词：Knee ; Genu recurvatum ; Deformity ; Brothers ; Osteoarthritis
• 刊名：The Lancet
• 出版年：2007
• 出版时间：17 November 2007-23 November 2007
• 年：2007
• 卷：370
• 期：9600
• 页码：1698-1705
• 全文大小：151 K

文摘

Intrapartum and neonatal single-dose nevirapine are essential components of perinatal HIV prevention in resource-constrained settings, but can induce resistance to other non-nucleoside reverse transcriptase inhibitor drugs. We aimed to investigate whether this complication would be reduced with a single peripartum intervention of tenofovir and emtricitabine.

Methods

We randomly assigned 400 HIV-infected pregnant women who sought care at two public-sector primary health facilities in Lusaka, Zambia. One was excluded, 200 were assigned to receive a single oral dose of 300 mg tenofovir disoproxil fumarate with 200 mg emtricitabine under direct observation, and 199 to receive no study drug. Short-course zidovudine and intrapartum nevirapine were offered to all HIV-infected women, according to the local standard of care. Women who met national criteria for antiretroviral therapy were referred for care and not enrolled. Our primary study outcome was resistance to non-nucleoside reverse transcriptase inhibitors at 6 weeks after delivery. We used standard population sequencing to determine HIV genotypes. Analysis was per protocol. This study is registered with ClinicalTrials.gov, number NCT00204308.

Findings

Of the 200 women who were randomly assigned to the intervention, 14 were lost to follow-up or withdrew from the study, two did not take study drug according to protocol, and one specimen was lost; 23 of 199 controls were lost to follow-up or withdrew from the study, and three specimens were lost. Women given the intervention were 53 % less likely than controls to have a mutation that conferred resistance to non-nucleoside reverse transcriptase inhibitors at 6 weeks after delivery (20/173 [12 % ] vs 41/166 [25 % ]; risk ratio [RR] 0·47, 95 % CI 0·29–0·76). We noted postpartum anaemia, the most common serious adverse event in mothers, in four women in each group. 20 of 198 (10 % ) infants in the intervention group and 23 of 199 (12 % ) controls had a serious adverse event, mostly due to septicaemia (n=22) or pneumonia (n=8); these events did not differ between groups, and none were judged to be caused by the study intervention.

Interpretation

A single dose of tenofovir and emtricitabine at delivery reduced resistance to non-nucleoside reverse transcriptase inhibitors at 6 weeks after delivery by half; therefore this treatment should be considered as an adjuvant to intrapartum nevirapine.