SIRT1 regulates accumulation of oxidized LDL in HUVEC via the autophagy-lysosomal pathway
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- 作者：Yanlin Zhanga ; 1 ; zhangyanlin0012006@163.com" class="auth_mail" title="E-mail the corresponding author ; Juanjuan Suna ; 1 ; 1531898573@qq.com" class="auth_mail" title="E-mail the corresponding author ; Xiaoyan Yua ; Luyao Shia ; Wenxiu Dua ; Lifang Hub ; Chunfeng Liua ; b ; Yongjun Caoa ; b ; yongjuncao@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：SIRT1 ; ox-LDL ; Accumulation ; HUVECs ; Autophagy-lysosomal pathway
- 刊名：Prostaglandins and Other Lipid Mediators
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：37-44
- 全文大小：2184 K
文摘
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SIRT1 can decrease the accumulation of ox-LDL in HUVECs.
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RSV increase the autophagic flux of HUVECs exposed to ox-LDL.
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Inhibition of autophagy by Atg 5 siRNA and chloroquine inhibit the effect of SIRT1.