Silver nanoparticle-gated fluorescence porous silica nanospheres for glutathione-responsive drug delivery

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• 作者：Li QiuAuthor Vitae ; Yanbao Zhao ; ^{yanbaozhao@126.com" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Na CaoAuthor Vitae ; Liuqin CaoAuthor Vitae ; Lei SunAuthor Vitae ; Xueyan ZouAuthor Vitae
• 关键词：Porous silica ; Glutathione-responsive ; Drug delivery
• 刊名：Sensors & Actuators: B. Chemical
• 出版年：2016
• 出版时间：29 October 2016
• 年：2016
• 卷：234
• 期：Complete
• 页码：21-26
• 全文大小：1192 K

文摘

To reduce the premature release of encapsulated drug, glutathione-responsive fluorescent porous silica (pSiO₂) nanocarriers were developed by encapsulating Ag nanoclusters (Ag NCs) and capped with Ag nanoparticles (Ag NPs). Ag NCs/porous silica (Ag NCs/pSiO₂) nanospheres (NSs) have an average diameter of 45 nm and large specific surface with Brunauer-Emmett-Teller (BET) area of 453 m² g⁻¹. After loading N-(2-Mercaptopropionyl) glycine (MPG), the absorbed Ag⁺ ions were in situ reduced to Ag NPs and capped on the outer surfaces of Ag NCs/pSiO₂ NSs as gatekeepers to regulate the release of drugs. In the absence of glutathione (GSH), the release rate is below 8% within 12 h; while in the presence of 2 mM GSH, the amount released reaches 70% within 8 h. The Ag NPs-gated Ag NCs/pSiO₂ NSs displayed excellent GSH-responsive release. The incorporated Ag NCs presented novel drug-dependent fluorescence, which could be used to trace the drug release. In addition, the Ag NPs-gated Ag NCs/pSiO₂ NSs displayed excellent antibacterial activity against both Gram-positive and Gram-negative bacteria.