Metabolomics Predicts Neuroimaging Characteristics of Transient Ischemic Attack Patients

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• 作者：Francisco Purroy ; MD ; PhD^a ; ^{fpurroygarcia@gmail.com} ; Serafi Cambray ; PhD^a ; ¹ ; Gerard Mauri-Capdevila ; MD^a ; ¹ ; Mariona Jové ; PhD^b ; ¹ ; Jordi Sanahuja ; MD^a ; Joan Farré ; ^c ; Ikram Benabdelhak^a ; Jessica Molina-Seguin^a ; Laura Colà ; s-Campà ; s^a ; Robert Begue^a ; M. Isabel Gil^a ; Reinald Pamplona ; MD ; PhD^b ; Manuel Portero-Otí ; n ; MD ; PhD^b ;
• 关键词：Diffusion magnetic resonance imaging ; Metabolomics ; TIA
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：14
• 期：Complete
• 页码：131-138
• 全文大小：766 K
• 卷排序：14

文摘

Metabolomics could identify plasmatic biomarkers related to acute ischemia and neuroimaging features among TIA patients Creatinine, lysophosphatidic acid, N-acetyl-glucosamine and Threonil-Threonine are potential Biomarkers for DWI positive Leucine levels correlate with Ischemic Volume Metabolomics identify specific ischemic DWI patterns among TIA patients.We used the metabolomic approach on two independent TIA cohorts (129 and 152 patients) to identify patients with positive DWI and also to obtain metabolomic profiles for specific acute ischemic patterns. We found that DWI positive patients showed a specific metabolomic profile in both cohorts. What is more, we also found a set of metabolites related to acute ischemic volume and also a specific metabolomic signature to determinate DWI patterns. These findings will help to develop specific tools for ischemia detection in TIA patients that are not able to undergo DWI imaging.