Validation of the 2013 American College of Rheumatology/European League Against Rheumatism classification criteria for systemic sclerosis in patients from a capillaroscopy clinic

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• 作者：Sheila Melchor ; MD^a ; Beatriz E. Joven ; MD^a ; Jose Luis Andreu ; MD ; PhD^b ; Estibaliz Loza ; MD^c ; M. Jesus Garcia de Yebenes ; MD^c ; Loreto Carmona ; MD ; PhD^c ; Patricia E. Carreira ; MD ; PhD^a ; ^{carreira@h12o.es}
• 关键词：Systemic sclerosis ; Classification criteria ; Validity
• 刊名：Seminars in Arthritis and Rheumatism
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：46
• 期：3
• 页码：350-355
• 全文大小：243 K
• 卷排序：46

文摘

To validate the 2013 ACR/EULAR classification criteria for systemic sclerosis (SSc) in patients from a capillaroscopy clinic.MethodsAll patients attended in a capillaroscopy clinic were included. Sociodemographic and SSc-related variables were collected. Using as gold standard for SSc the clinical judgement, the performance (sensitivity, specificity, predictive values, and likelihood ratios) of the 2013 ACR/EULAR criteria were analyzed. Receiver operating characteristic (ROC) curve and the area under the curve (AUC) were calculated for the global score and individual items, and the best cutoffs were obtained.ResultsWe included 327 patients (84% women, mean age at capillaroscopy 48 years). Main reasons for capillaroscopy referral were Raynaud’s phenomenon (39%) and SSc evaluation (27%). The most frequent final clinical diagnosis were SSc (32.4%) and primary Raynaud’s phenomenon (25.7%). The 2013 ACR/EULAR SSc classification criteria were met by 116 patients (35.5%). Sensitivity and specificity of the new criteria were 98.1% and 94.6%, respectively, and positive and negative predictive values were 89.7% and 99.1%. The individual variables with the best sensitivity were Raynaud’s phenomenon (99.1%) and abnormal nailfold capillaries (81.1%). All the individual variables, except Raynaud’s phenomenon, puffy fingers and sclerodactily showed high specificity values, over 90%. The best cutoffs of the total score were ≥8, ≥9, and ≥10, and the AUC = 0.993.ConclusionsWe validated the new ACR/EULAR classification criteria for SSc in unselected patients from a capillaroscopy clinic. Global score and individual items included in the new criteria show high diagnostic accuracy and discriminatory capacity.