rAAV2/9-Exon 1 HTT 17 or 138 CAG was used to create a new rat model of HD.
Exon 1 HTT-Q138 induced neurodegeneration and neuroinflammation in the striatum.
Genomic analysis and H1-MRS study revealed high association with human HD hallmarks.
We pharmacologically validated our model using cystamine.
Our model provide useful tool for drug discovery process.