Subcutaneous injection of exosomes reduces symptom severity and mortality induced by Echinostoma caproni infection in BALB/c mice
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- 作者：Maria Trelisa ; b ; Alicia Galianoa ; Anabel Boladoa ; Rafael Toledoa ; Antonio Marcillaa ; b ; Dolores Bernalc ; m.dolores.bernal@uv.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Helminth ; Echinostoma caproni ; Exosome ; Extracellular vesicles ; Immunomodulation ; BALB/c mice
- 刊名：International Journal for Parasitology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：46
- 期：12
- 页码：799-808
- 全文大小：1225 K
文摘
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Exosomes reduce symptom severity and mortality induced by Echinostoma caproni in BALB/c mice.
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Immunisation with exosomes generates systemic and local antibody responses.
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Exosomes carry specific antigens that are involved in the immune response.
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Cytokine increase in spleen suggests a Th2/Treg phenotype.
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Modulation of the immune system offers a novel therapeutic use of parasitic exosomes.