¹⁰B-editing ¹H-detection and ¹⁹F MRI strategies to optimize boron neutron capture therapy

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• 作者：Silvia Capuani ; Paola Porcari ; Fabrizio Fasano ; Renzo Campanella ; Bruno Maraviglia
• 关键词：BNCT ; ¹⁹F-MRI ; ¹⁰B ; J-coupled protons ; Glioma rat brain
• 刊名：Magnetic Resonance Imaging
• 出版年：2008
• 出版时间：September 2008
• 年：2008
• 卷：26
• 期：7
• 页码：987-993
• 全文大小：552 K

文摘

Boron neutron capture therapy (BNCT) is a binary radiation therapy used to treat malignant brain tumours. It is based on the nuclear reaction (¹⁰B + n_th → [¹¹B*] → α + ⁷Li + 2.79 MeV) that occurs when ¹⁰B captures a thermal neutron to yield α particles and recoiling ⁷Li nuclei, both responsible of tumour cells destruction by short range and high ionization energy release. The clinical success of the therapy depends on the selective accumulation of the ¹⁰B carriers in the tumour and on the high thermal neutron capture cross-section of ¹⁰B. Magnetic resonance imaging (MRI) methods provide the possibility of monitoring, through ¹⁰B nuclei, the metabolic and physiological processes suitable to optimize the BNCT procedure. In this study, spatial distribution mapping of borocaptate (BSH) and 4-borono-phenylalanine (BPA), the two boron carriers used in clinical trials, has been obtained. The BSH map in excised rat brain and the ¹⁹F-BPA image in vivo rat brain, representative of BPA spatial distribution, were reported. The BSH image was obtained by means of double-resonance ¹⁰B-editing ¹H-detection sequence, named M-Bend, exploiting the J-coupling interaction between ¹⁰B and ¹H nuclei. Conversely, the BPA map was obtained by ¹⁹F-BPA using ¹⁹F-MRI. Both images were obtained at 7 T, in C6 glioma-bearing rat brain. Our results demonstrate the powerful of non conventional MRI techniques to optimize the BNCT procedure.