Water diffusion in cancellous bone
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- 作者：Silvia Capuani
- 关键词：Cancellous bone ; Apparent diffusion coefficient ; ADC ; Osteoporosis ; Water diffusion
- 刊名：Microporous and Mesoporous Materials
- 出版年：2013
- 出版时间：15 September, 2013
- 年：2013
- 卷：178
- 期：Complete
- 页码：34-38
- 全文大小：791 K
文摘
In this paper, by means of in vivo experiments, a porous system model suitable for investigating the structural properties of cancellous bone by using diffusion MRI techniques is described and corroborated. Toward this goal a cancellous bone model is described on the basis of some recent evidence obtained in both calf bone samples and human vertebrae. Then, the calcaneus and the femoral neck of healthy, osteopenic and osteoporotic subjects were investigating, as classified by the bone mineral density (BMD) parameter, by measuring the apparent diffusion coefficient (ADC), together with the marrow fat content (Mfc) and assessing associations between bone mineral-density index T-score, Mfc and ADC. MR spectroscopy (1H-MRS) and diffusion weighted imaging (DWI) with b-value = 2500 s/mm2 and b-value = 8000 s/mm2 to investigate femoral neck and calcaneus, respectively, were obtained in each subject using a 3T MR scanner. One-way ANOVA and Pearson correlation analyses were applied.
ADC results as a function of Mfc and BMD obtained in calcaneus and femoral neck, seem to validate the cancellous bone model described in this paper. Although the MR results are still preliminary, and based on a small number (n = 60) of subjects, they suggest the ability of the ADC parameter to identify enhanced risk of osteoporosis. As a consequence, diffusion assessment in combination with 1H-MRS investigations obtained in large populations, might increase our pathophysiological understanding of osteoporosis and might also improve the diagnosis of osteoporosis.