Ghrelin modulates gene and protein expression of digestive enzymes in the intestine and hepatopancreas of goldfish (Carassius auratus) via the GHS-R1a: Possible roles of PLC/PKC and AC/PKA intracellular signaling pathways

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• 作者：Ayelé ; n Melisa Blanco^a ; ^b ; ^{ayelenmelisablanco@ucm.es} ; Juan Ignacio Bertucci^a ; ^c ; ^{jbertucci@intech.gov.ar} ; Aí ; da Sá ; nchez-Bretañ ; o^d ; ^{asanchez@msm.edu} ; Marí ; a Jesú ; s Delgado^b ; ^{mjdelgad@bio.ucm.es} ; Ana Isabel Valenciano^b ; ^{aivalenciano@bio.ucm.es} ; Suraj Unniappan^a ; ^{suraj.unniappan@usask.ca}
• 关键词：Fish ; Ghrelin ; Sucrase-isomaltase ; Aminopeptidase ; Trypsin ; Lipoprotein lipase
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：442
• 期：Complete
• 页码：165-181
• 全文大小：6720 K
• 卷排序：442

文摘

Ghrelin and GHS-R1a colocalize digestive enzymes in goldfish intestine and hepatopancreas. Ghrelin induces sucrase-isomaltase, aminopeptidase A and lipoprotein lipase expression in vitro. GHS-R1a is critical for ghrelin-induced upregulation of digestive enzymes. Ghrelin actions on digestive enzymes might be partly mediated by PLC/PKC and AC/PKA signaling pathways.