Phase I metabolism of 3-methylindole, an environmental pollutant, by hepatic microsomes from carp (Cyprinus carpio) and rainbow trout (Oncorhynchus mykiss)
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- 作者：Vladimir Zlabeka ; vzlabek@frov.jcu.cz" class="auth_mail" title="E-mail the corresponding author ; Viktoriia Burkinaa ; vburkina@frov.jcu.cz" class="auth_mail" title="E-mail the corresponding author ; Francesc Borrisser-Pairó ; b ; francesc.borrisser@irta.cat" class="auth_mail" title="E-mail the corresponding author ; Sidika Sakallia ; sakalli@frov.jcu.cz" class="auth_mail" title="E-mail the corresponding author ; Galia Zamaratskaiaa ; c ; Galia.Zamaratskaia@slu.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hepatic microsomes ; 3-methylindole ; 3-hydroxy-3-metyloxindole ; Indole-3-carbinol ; Cytochrome P450
- 刊名：Chemosphere
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：150
- 期：Complete
- 页码：304-310
- 全文大小：989 K
文摘
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metabolism of 3-methylindole (3MI, skatol) was described in fish.
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3MI is metabolised in fish liver to 3MOI and I3C by CYP450.
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carp microsomes produced only one metabolite, 3MOI.
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rainbow trout microsomes produced both 3MOI and I3C.