Biotinylated N-palmitoyl chitosan for design of drug loaded self-assembled nanocarriers
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- 作者：Vera Balana ; Valentina Redinciuca ; Nita Tudorachib ; Liliana Verestiuca ; liliana.verestiuc@bioinginerie.ro" class="auth_mail" title="E-mail the corresponding author
- 关键词：BPCs ; biotinylated N-palmitoyl chitosan ; CMC ; critical micelle concentration ; DCX ; Docetaxel ; DCX-NP ; docetaxel-loaded nanoparticles ; DL ; drug loading ; DLS ; dynamic light scattering ; DMSO ; dimethyl sulfoxide ; EDAC ; 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride ; EE ; entrapment efficiency ; GPC ; gel permeation cromatography ; 1H NMR ; Proton Nuclear Magnetic Resonance ; Mn ; number-average molecular weight ; Mw ; weight-average molecular weight ; NHS ; N-hydroxysuccinimide ; PCs ; N-palmitoyl
- 刊名：European Polymer Journal
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：81
- 期：Complete
- 页码：284-294
- 全文大小：1942 K
文摘
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N-palmitoyl chitosan is biofunctionalized with biotin, via carbodiimide chemistry.
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10">Biotinylated N-palmitoyl chitosan is able to self-assemble as nanocarriers.
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15">Chemotherapeutic agents are entrapped simultaneously with nanocarrier generation.
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Nanoparticles exhibit a pH-dependent release profile, biodegradability and hemocompatibility.