Luminescent nanocrystal metal organic framework based biosensor for molecular recognition

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• 作者：Pawan Kumar^a ; ^b ; ^{pawannano10@gmail.com" class="auth_mail} ; Parveen Kumar^a ; Lalit M. Bharadwaj^c ; A.K. Paul^a ; ^b ; Akash Deep^a ; ^b ; ¹ ; ^{dr.akashdeep@gmail.com" class="auth_mail}
• 关键词：MOF ; Cd(II) ; atc ; Bioconjugation ; Sensing ; Anti-bovine serum albumin
• 刊名：Inorganic Chemistry Communications
• 出版年：May, 2014
• 年：2014
• 卷：43
• 期：Complete
• 页码：114-117
• 全文大小：550 K

文摘

A nanocrystal metal organic framework (NMOF1) has been investigated for molecular recognition. NMOF1 {[Cd(atc)(H₂O)₂]_n} has been synthesized by the reaction of Cd(II) ions with the sodium salt of 鈥?em>atc鈥?(鈥?em>atc鈥?#xA0;= 2-aminoterephthalic acid) in aqueous medium at room temperature. Pendent COOH group of the organic linker was activated using EDC [(1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide] intermediated organic reaction, followed by the bioconjugation of NMOF1 with anti-BSA (anti-bovine serum albumin). NMOF1/anti-BSA complex has been used for the sensing of BSA (bovine serum albumin) based on the fluorescence quenching phenomena. Estimated limit of detection of the proposed molecular probe is 7 mg/mL.