Investigating the potential of combined growth factors delivery, from non-mulberry silk fibroin grafted poly(ɛ-caprolactone)/hydroxyapatite nanofibrous scaffold, in bone tissue engineering

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• 作者：Promita Bhattacharjee^a ; ^{promitabhatt@gmail.com} ; Deboki Naskar^b ; Tapas K. Maiti^b ; Debasis Bhattacharya^a ; Subhas C. Kundu^b ; ^c
• 关键词：Non-mulberry silk fibroin ; Aminolysis ; Growth factors ; Alternative soaking ; Bone tissue engineering
• 刊名：Applied Materials Today
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：5
• 期：Complete
• 页码：52-67
• 全文大小：7454 K
• 卷排序：5

文摘

Non-mulberry silk fibroin was grafted onto nanofibrous PCL matrices. HAp was inculcated in these matrices via alternative soaking. HAp inclusion improved strength and biocompatibility of matrices. Carbodiimide coupling was used to load the composite scaffolds with growth factors. Dual growth factor loaded scaffold gave best cell growth and differentiation result.