Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways
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- 作者：Gabriel A. Rabinovich1 ; 2 ; gabyrabi@gmail.com" class="auth_mail" title="E-mail the corresponding author ; José ; R. Conejo-Garcí ; a3
- 关键词：CTL ; cytotoxic T lymphocytes ; CTLA-4 ; cytotoxic T-lymphocyte antigen 4 ; CRD ; carbohydrate-recognition domain ; DCs ; dendritic cells ; EC ; endothelial cell ; IL ; interleukin ; LacNAc ; N-acetyllactosamine ; LAG-3 ; MDSCs ; myeloid-derived suppressor cells ; MHC ; major histocompatibility complex ; MICA ; major histocompatibility complex class I-related chain A ; TCR ; T-cell receptor ; TGF-β ; transforming growth factor-β ; TIM-3 ; T-cell immunoglobulin and mucin-domain containing-3 ; TME ; tumor microenvironment ; T
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：14 August 2016
- 年：2016
- 卷：428
- 期：16
- 页码：3266-3281
- 全文大小：1038 K
文摘
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Galectins are key players in immune evasion programs in cancer.
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Galectins–glycan interactions control immune and endothelial cell compartments.
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Galectin-1 links commensal microbiota, systemic inflammation, and tumor-immune escape.
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Targeting galectin–glycan interactions may contribute to unleashing antitumor immunity.