HEMODYNAMIC CHANGES DO NOT MEDIATE THE CARDIOPROTECTION INDUCED BY THE A₁, ADENOSINE RECEPTOR AGONIST CCPA IN THE RABBIT

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• 作者：CASATI ; CARLO ; FORLANI ; ANGELO ; LOZZA ; GIANLUCA ; MONOPOLI ; ANGELA
• 刊名：Pharmacological Research
• 出版年：1997
• 出版时间：January, 1997
• 年：1997
• 卷：35
• 期：1
• 页码：51-55
• 全文大小：82.3 K

文摘

Stimulation of adenosine A₁receptors is known to reduce infarct size in the rabbit heart. The aim of the present study was to verify whether a protective activity similar to that of the selective A₁receptor agonist, 2-chloro-N⁶-cyclopentyladenosine (CCPA), could also be obtained by inducing comparable hemodynamic effects with drugs having different mechanisms of action. The effects of theβ-adrenoceptor blocker atenolol, the calcium channel blocker felodipine, the A^2A-selective adenosine receptor agonist 2-hexynyl-5′-N-ethyl-carboxamidoadenosine (2HE-NECA), and the non-selective adenosine receptor agonist 5′-N-ethyl-carboxamidoadenosine (NECA) were tested.