Carboxyl-functionalized graphene oxide composites as SPR biosensors with enhanced sensitivity for immunoaffinity detection
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- 作者：Nan-Fu Chiu ; nfchiu@ntnu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Shi-Yuan Fan ; Cheng-Du Yang ; Teng-Yi Huang
- 关键词：Surface plasmon resonance (SPR) ; Carboxyl-functionalized graphene oxide (GO-COOH) ; Immunoaffinity ; Biocompatible ; Biosensor
- 刊名：Biosensors and Bioelectronics
- 出版年：2017
- 出版时间：15 March 2017
- 年：2017
- 卷：89
- 期：part_P1
- 页码：370-376
- 全文大小：2561 K
文摘
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Covalently linked biocompatible GO–COOH composites are utilized in SPR-based immunoaffinity biosensors.
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The affinity binding value of the Au/GO–COOH chip was up to ~5.15 times that of the Au/GO chip.
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The detection limit of the Au/GO–COOH chip is 0.01 pg/ml, with a correlation coefficient of 0.973 at linear range of 0.01–100 pg/ml.