The Von Willebrand Factor A1-Collagen III Interaction Is Independent of Conformation and Type 2 Von Willebrand Disease Phenotype

详细信息    查看全文

• 作者：Venkata R. Machha ; Alexander Tischer ; Laurie Moon-Tasson ; Matthew Auton ; ^{auton.matthew@mayo.edu}
• 关键词：SPR ; surface plasmon resonance ; CD ; circular dichroism ; VWF ; von Willebrand factor ; ULVWF ; unusually large von Willebrand factor ; VWD ; von Willebrand disease ; DDAVP ; 1-desamino-8-d-arginine vasopressin ; RCAM ; reduced and carboxyamidated
• 刊名：Journal of Molecular Biology
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：429
• 期：1
• 页码：32-47
• 全文大小：1774 K
• 卷排序：429

文摘

The VWF A1–collagen–GPIbα ternary interaction is not conformationally coupled. VWF A1 binding to collagen is independent of type 2 VWD phenotype. VWF A1 affinity for platelet GPIbα is down-regulated in the presence of collagen.