Adenosine A_2A receptors inhibit the N-methyl--aspartate component of excitatory synaptic currents in rat striatal neurons

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• 作者：Gerevich ; Zoltan ; Wirkner ; Kerstin ; Illes ; Peter
• 关键词：Patch-cl whole-cell ; Adenosine A_2A receptor ; NMDA receptor ; Striatum
• 刊名：European Journal of Pharmacology
• 出版年：2002
• 出版时间：September 13, 2002
• 年：2002
• 卷：451
• 期：2
• 页码：161-164
• 全文大小：147 K

文摘

The effects of the adenosine A_2A receptor agonist 2-p-(2-carboxyethyl)phenethyl-amino-5′-N-ethylcarboxamidoadenosine (CGS 21680) on currents mediated by excitatory amino acid receptors were examined in rat striatal brain slices. In a Mg²⁺-free superfusion medium, CGS 21680 decreased the amplitude of excitatory postsynaptic currents (EPSCs) in about 70 % of striatal neurons. The inhibitory effect of CGS 21680 disappeared both in the presence of the adenosine A_2A receptor antagonist 8-(3-chlorostyryl) caffeine and the NMDA receptor antagonist 2-amino-5-phosphonopentanoic acid (AP-5). NMDA-induced currents were also depressed by CGS 21680 in a subset of striatal cells, whereas ^5;-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)-induced currents were not affected. The results suggest that adenosine A_2A receptor agonists inhibit the NMDA component of the EPSC.