Sargachromenol protects against vascular inflammation by preventing TNF-α-induced monocyte adhesion to primary endothelial cells via inhibition of NF-κB activation

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• 作者：Wi-Gyeong Gwon^a ; Eun-Ji Joung^a ; Mi-Sung Kwon^a ; Su-Jin Lim^a ; Tadanobu Utsuki^b ; Hyeung-Rak Kim^a ; ^{hrkim@pknu.ac.kr}
• 关键词：BCECF-AM ; 2&prime ; 7&prime ; -Bis(2-carboxyethyl)-5(6)-carboxyfluorescein acetoxy-methylester ; BSA ; bovine serum albumin ; DAPI ; 4&prime ; 6-diamidino-2-phenylindole ; DCFH-DA ; 2&prime ; 7&prime ; -dichlorofluorescin diacetate ; 4&rsquo ; 6-diamidino-2-phenylindole ; DMSO ; dimethyl sulfoxide ; ECL ; enhanced chemiluminescence ; EGM-2 ; endothelial cell growth medium ; HUVEC ; human umbilical vein endothelial cell ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; ICAM-1 ; intracellular adhesion molecule-1 ; IκB-α
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：42
• 期：Complete
• 页码：81-89
• 全文大小：925 K
• 卷排序：42

文摘

Sargachromenol (SCM) was isolated from Sargassum serratifolium. SCM inhibited the adhesion of THP-1 to TNF-α-stimulated endothelium. SCM inhibited the expression of ICAM-1, VCAM-1, and MCP-1 via NF-κB pathway. SCM could be a novel therapeutic agent to treat vascular inflammatory diseases.