Commercial gold nanocolloid inhibits synthesis of IL-2 and proliferation of porcine T lymphocytes

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• 作者：Joanna Małaczewska^a ; ^{joanna.malaczewska@uwm.edu.pl} ; Roman Wó ; jcik^a ; Edyta Kaczorek^a ; Wojciech Rękawek^b ; Andrzej Krzysztof Siwicki^a
• 关键词：AuNPs ; Gold nanoparticles ; FB ; Facs buffer ; CFSE ; Carboxyfluorescein diacetate succinimidyl esther ; SP ; Single positive ; DP ; Double positive ; DN ; Double negative ; C ; Control cells
• 刊名：Research in Veterinary Science
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：110
• 期：Complete
• 页码：4-11
• 全文大小：1138 K
• 卷排序：110

文摘

Commercial gold nanocolloid is not cytotoxic to porcine peripheral blood mononuclear cells. Investigated nanocolloid does not affect resting porcine T cells. High nanocolloid concentration inhibits ConA-stimulated proliferation of T cells by down-regulation of the IL-2 synthesis. The most affected by nanogold subpopulation were double negative CD4−CD8α− T cells.