Regulation of hepatic energy metabolism by the nuclear receptor PXR
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- 作者：Jukka Hakkolaa ; b ; jukka.hakkola@oulu.fi" class="auth_mail" title="E-mail the corresponding author ; Jaana Rysä ; c ; Janne Hukkanenb ; d ; e ; f
- 关键词：ACAA2 ; acetyl-CoA acyltransferase 2 ; ACC1 ; acetyl-CoA carboxylase 1 ; ACL ; adenosine triphosphate citrate lyase ; ACOX1 ; acyl-coenzyme A oxidase 1 ; AKR1B10 ; aldo&ndash ; keto reductase 1B10 ; CAR ; constitutive androstane receptor ; CD36 ; cluster of differentiation 36 ; CPT1A ; carnitine palmitoyltransferase 1A ; CREB ; cAMP response element-binding protein ; CYP ; cytochrome P450 ; ELOVL6 ; elongation of very-long-chain fatty acids 6 ; FAS ; fatty acid synthase ; FOX ; forkhead box protein ; G6Pase ; glucose-6-phos
- 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1859
- 期：9
- 页码：1072-1082
- 全文大小：771 K
文摘
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Nuclear receptor PXR senses chemical environment.
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PXR regulates hepatic glucose and lipid metabolism.
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PXR activation represses β-oxidation and induces lipogenesis in cell models.
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PXR activation impairs postprandial glucose tolerance in humans.
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Chronic exposure to PXR agonists may predispose to diabetes and metabolic syndrome.