Synthesis and characterization of biodegradable chitosan beads as nano-carriers for local delivery of satranidazole
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- 作者：Mohammad Reza Saboktakin ; Roya M. Tabatabaie ; Abel Maharramov ; Mohammad Ali Ramazanov
- 关键词：Hydrogel beads ; N-sulfonato-N ; O-carboxymethylchitosan ; Polymethacrylic acid ; Local delivery ; Satranidazole
- 刊名：Carbohydrate Polymers
- 出版年：2010
- 出版时间：7 July 2010
- 年：2010
- 卷：81
- 期：3
- 页码：726-731
- 全文大小：725 K
文摘
The main aim of this research is to design a new extended release gastroretentive multiparticulate delivery system by incorporation of the hydrogel beads made of chitosan. As the first part of a continued research on conversion of N-sulfonato-N,O-carboxymethylchitosan(NOCCS) to useful biopolymer-based materials, large numbers of carboxylic functional groups were introduced onto NOCCS by grafting with polymethacrylic acid (PMAA). The free radical graft copolymerization was carried out at 70 °C, bis-acrylamide as a cross-linking agent and persulfate as an initiator. The equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively). Also, the satranidazole as a model drug was entrapped in nano-gels and in vitro release profiles were established separately in both enzyme-free SGF and SIF. The drug release was found to be faster in SIF. The drug-release profiles indicate that the drug release depends on their degree of swelling and cross-linking.