Synthesis and in vitro studies of biodegradable modified chitosan nanoparticles for photodynamic treatment of cancer

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• 作者：Mohammad  ; Reza Saboktakin^a ;   ; ^b ;   ; ^{saboktakin123@yahoo.com} ; Roya M.  ; Tabatabaie^a ; Abel  ; Maharramov^b ; Mohammad  ; Ali Ramazanov^b
• 关键词：Modified chitosan ; In vitro ; Biodegradable ; Photodynamic ; Cancer
• 刊名：International Journal of Biological Macromolecules
• 出版年：2011
• 出版时间：1 December 2011
• 年：2011
• 卷：49
• 期：5
• 页码：1059-1065
• 全文大小：765 K

文摘

The main aim of this research is to study the in vitro photocytotoxicity and cellular uptake of biodegradable polymeric nanoparticles loaded with photosensitizer mTHPP. As the first part of a continued research on conversion of N-sulfonato-N,O-carboxymethylchitosan (NOCCS) to useful biopolymer-based materials, large numbers of carboxylic functional groups were introduced onto NOCCS by grafting with polymethacrylic acid (PMAA). The free radical graft copolymerization was carried out at 70 ¡ãC, bis-acrylamide as a cross-linking agent and persulfate as an initiator. These results show that the nanoparticles have high loading capacity and stability. These nanoparticles are suitable as carriers for photodynamic therapy in vivo.