Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain
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- 作者：Zhi Zhanga ; Bassam Bassama ; Ajit G. Thomasc ; Monica Williamsa ; Jinhuan Liua ; Elizabeth Nancea ; Camilo Rojasc ; Barbara S. Slusherb ; c ; Sujatha Kannana ; skannan3@jhmi.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cerebral palsy ; Periventricular leukomalacia ; Glutamate ; Glutamate carboxypeptidase II (GCPII) ; Microglia ; Astrocytes ; Rabbit
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：94
- 期：Complete
- 页码：116-128
- 全文大小：2894 K
文摘
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Maternal inflammation leads to glutamate dysregulation in the fetal/newborn brain.
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Glutamate carboxypeptidase II is upregulated in ‘activated’ microglia.
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Inflammation results in changes in astrocyte morphology in the white matter tracts.
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Intrauterine endotoxin exposure leads to decreased TGF-β1 in the newborn brain.