Anti-inflammatory and anti-fibrinolytic effects of thrombomodulin alfa through carboxypeptidase B2 in the presence of thrombin
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- 作者：Shunsuke Tawara ; tawara.sc@om.asahi-kasei.co.jp" class="auth_mail" title="E-mail the corresponding author ; Takumi Sakai ; Osamu Matsuzaki
- 关键词：CPB2 ; carboxypeptidase B2 ; CPI ; carboxypeptidase inhibitor from potato tuber ; DIC ; disseminated intravascular coagulation ; HSA ; human serum albumin ; pan-CPB ; carboxypeptidase B from porcine pancreas ; PMN ; polymorphonuclear neutrophil ; pro-CPB2 ; pro-carboxypeptidase B2 ; TAFI ; thrombin-activatable fibrinolysis inhibitor ; TM ; thrombomodulin ; t-PA ; tissue-type plasminogen activator
- 刊名：Thrombosis Research
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：147
- 期：Complete
- 页码：72-79
- 全文大小：717 K
文摘
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TM alfa inhibits thrombin generation and enhances pro-CPB2 activation in plasma.
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TM alfa inactivates C5a by removal of the C-terminal arginine via CPB2.
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TM alfa inhibits C5a-induced human neutrophil migration through CPB2.
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TM alfa prolongs clot lysis time in a CPB2-dependent manner.