Classification schemes for carcinogenicity based on hazard-identification have become outmoded and serve neither science nor society

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• 作者：Alan R. Boobis^a ; Samuel M. Cohen^b ; Vicki L. Dellarco^c ; John E. Doe^d ; ^{john.doe@parkerdoe.com} ; Penelope A. Fenner-Crisp^e ; Angelo Moretto^f ; Timothy P. Pastoor^g ; Rita S. Schoeny^h ; Jennifer G. Seedⁱ ; Douglas C. Wolf^j
• 关键词：Classification ; Hazard characterization ; Risk assessment ; Carcinogenicity ; IARC ; GHS
• 刊名：Regulatory Toxicology and Pharmacology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：82
• 期：Complete
• 页码：158-166
• 全文大小：312 K
• 卷排序：82

文摘

Cancer classification on hazard-identification such as IARC and UN GHS are outmoded. Chemicals with differences in potency and modes of action placed in same category. Unintended consequences: health scares, costs, and diversion of public funds. Modern approaches based on hazard and risk characterization should be used. International initiative needed a consensus on for carcinogenicity.