Laparoscopic transgastric esophageal mucosal resection: a treatment option for patients with high-grade dysplasia in Barrett's esophagus

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• 作者：Constantine T. Frantzides ; M.D.^a ; ^{shaun_daly@rush.edu" class="auth_mail" title="E-mail the corresponding author} ; Shaun C. Daly ; M.D.^b ; Alexander T. Frantzides ; M.D.^a ; Thomas Manelis ; M.D.^a ; Algis Marcinkevicius ; M.D.^a ; Minh B. Luu ; M.D.^b
• 关键词：Mucosal resection ; Endoscopic resection ; High-grade dysplasia ; Barrett's esophagus
• 刊名：The American Journal of Surgery
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：211
• 期：3
• 页码：534-536
• 全文大小：131 K

文摘

We present long-term follow-up data on patients with esophageal high-grade dysplasia and/or carcinoma in situ who were treated with laparoscopic transgastric esophageal mucosal resection (LTEMR).

Methods

Patient demographics, operative outcomes, and follow-up results were tabulated.

Results

LTEMR was performed in 11 patients (9 male, 2 female). The median age was 54 (44 to 75) years. The 30-day morbidity or mortality was zero. The median follow-up was 5.2 (2 to 12) years. Upper endoscopy was performed at 3, 6, and 12 month, and yearly thereafter. All patients regenerated squamous epithelium at 6 months. One patient developed a recurrence of Barrett's epithelium 2 years after resection. No recurrences of high-grade dysplasia or carcinoma were observed in any of the patients. Two patients developed an esophageal stricture; both were treated successfully with endoscopic balloon dilation and have suffered no further sequelae.

Conclusions

LTEMR is safe and effective alternative method to treat patients with Barrett's esophagus with high-grade dysplasia.