Aberrant frequency of IL-10-producing B cells and its association with Treg and MDSC cells in Non Small Cell Lung Carcinoma patients

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• 作者：Jinlin Liu^a ; Huan Wang^a ; Qinhua Yu^a ; Sujie Zheng^a ; Yangcheng Jiang^b ; Yiyan Liu^b ; Guorong Yuan^c ; Liannv Qiu^a ; ^{qlv2012@126.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：NSCLC ; Non Small Cell Lung Carcinoma ; Treg cells ; regulatory T cells ; MDSCs ; myeloid-derived suppressor cells
• 刊名：Human Immunology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：77
• 期：1
• 页码：84-89
• 全文大小：1264 K

文摘

B regulatory cells (Bregs) are a newly described subpopulation of B cells that play important roles in autoimmunity, however, whether play an important role in cancer is relatively unknown. Herein, we investigated the role of IL-10 producing B cells in Non Small Cell Lung Carcinoma (NSCLC).

Methods

18 healthy controls (HC) and 66 untreated patients with NSCLC were enrolled. Next to IL-10 producing B cells, CD4⁺CD25^+/highCD127^low/− regulatory T (Treg) cells and CD14⁺HLA-DR^low/− myeloid-derived suppressor cells (MDSCs) were determined via flow cytometry.

Results

Upregulation of IL-10 producing B cells was associated with the NSCLC progression. Furthermore, this B cell subset was positively correlated with the frequency of CD4⁺CD25^+/highCD127^low/− Treg cells, also with the frequency of CD14⁺HLA-DR^low/− MDSCs in these NSCLC patients.

Conclusions

Together, IL-10 producing B cells are significantly elevated in NSCLC patients, indicating this B cell subset might play an important role in the clinical progression of NSCLC.