Loss of BRCA1-associated protein 1 (BAP1) expression is rare in non-small cell lung cancer

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• 作者：Daniel Owen ; MD^a ; ^{daniel.owen@alumni.ubc.ca} ; Brandon S. Sheffield ; MD^b ; ^{brandon.s.sheffield@gmail.com} ; Diana Ionescu ; MD^c ; ^{DIonescu@bccancer.bc.ca} ; Andrew Churg ; MD^a ; ^{achurg@mail.ubc.ca}
• 关键词：BAP1 ; Mesothelioma ; Lung adenocarcinoma ; Non&ndash ; small cell lung cancer ; Pleural metastasis ; Mesothelial hyperplasia
• 刊名：Human Pathology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：82-85
• 全文大小：852 K
• 卷排序：60

文摘

BRCA1-associated protein 1 (BAP1) is a tumor suppressor gene involved in regulation of the cell cycle, cellular differentiation, repair of DNA damage, and apoptosis. In the distinction of malignant mesothelioma from benign mesothelial proliferations, immunohistochemical loss of BAP1, the protein expressed by the BAP1 gene, has proven highly specific for malignant mesothelioma. However, few studies have investigated the rate of BAP1 loss in tumors that commonly metastasize to the pleura. Our objective is to determine the rate of BAP1 loss in non–small cell lung cancer (NSCLC). Immunohistochemistry for BAP1 was performed using tissue microarrays containing 133 confirmed cases of NSCLC (80 of lung adenocarcinoma and 53 of squamous cell carcinoma). Cases were interpreted as showing BAP1 loss if nuclear staining was completely absent in all tumor cells and present in stromal and inflammatory cells that served as internal controls. Cases showing no BAP1 staining in the internal controls were excluded. After exclusion of 32 cases for technical reasons, only 1 case of pulmonary adenocarcinoma of 101 cases of NSCLC (69 adenocarcinoma and 32 squamous cell carcinoma; 1.0% of cases) showed BAP1 loss. We conclude that loss of BAP1 expression is a rare event in NSCLC. Therefore, BAP1 is a potentially useful addition to the immunohistochemical markers used to distinguish mesothelioma from pleural metastasis of NSCLC.