CD19+IL-10+ regulatory B cells affect survival of tongue squamous cell carcinoma patients and induce resting CD4+ T cells to CD4+Foxp3+ regulatory T cells
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- 作者：Xi Zhoua ; Yu-Xiong Sub ; Xiao-Mei Laoa ; Yu-Jie Lianga ; 1 ; yujie0350@126.com" class="auth_mail" title="E-mail the corresponding author ; Gui-Qing Liaoa ; 1 ; drliaoguiqing@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Immunosuppression ; Tregs ; Bregs ; Tumor microenvironment ; IL-10 ; CD40L ; Tumor immunity ; Double staining ; Oral oncology ; Tongue squamous cell carcinoma
- 刊名：Oral Oncology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：53
- 期：Complete
- 页码：27-35
- 全文大小：3570 K
文摘
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Bregs in TSCC microenvironment was correlated with clinicopathological features and survival.
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TSCC microenvironment induce the differentiation or recruitment of Breg.
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Bregs induced by TSCC cells could convert CD4+CD25− T cells into Tregs through secretion of IL-10.